The invention discloses a respiratory tract prevention and cure drug for animals and a preparation method thereof, and relates to the technical field of animal medicine. The respiratory tract prevention and cure drug for animals is prepared from pidotimod, moringa oleifera, melatonin, microalgae and complex beneficial microorganisms; the preparation method includes the steps that the pidotimod, the moringa oleifera, the melatonin, the microalgae and the complex beneficial microorganisms are mixed together and uniformly, then the respiratory tract prevention and cure drug for animals is obtained. The respiratory tract prevention and cure drug for animals alleviates the current problems that the treatment of animal respiratory diseases depends mainly on antibiotics, and the treatment time islong, and resistance in the treatment process is easy to develop, the respiratory tract prevention and cure drug for animals is as an auxiliary medicine for treating respiratory diseases, can shortenthe treatment cycle of respiratory tract medicine to respiratory diseases, has a good curative effect, the animal can get a clear effect within a week, and the efficiency can reach above 96%.