A liquid chromatogram-tandem-mass spectrometry method for simultaneously detecting five types of medicines in animal edible products and feed is disclosed. The five types of medicines are epinephrinetype medicines, steroid hormones, psychotropic medicines, coloring agents and antioxidants. The method belongs to the technical field of medicine residual detection and analysis. The method includes two steps, namely a step of sample pretreatment and a step of liquid chromatogram-tandem-mass spectrometry detection. The method enriches and completes present detection techniques, can simultaneouslymeasure 88 medicines, and is simple, convenient and rapid to operate, and suitable for simultaneous detection of a plurality of medicines in feed and a plurality of animal foods.