The invention belongs to the technical field of unmanned driving and discloses a multiple sensor-integrated medium-speed unmanned vehicle detection and obstacle avoidance system, which comprises a control system, a vehicle roof laser radar, a vehicle-mounted monocular vision camera, a front laser radar group and a rear laser radar group, wherein the vehicle roof laser radar is used for detecting ups and downs of a road in front of the unmanned vehicle and together with the front laser radar group, detecting the obstacle condition in a front motion path of the unmanned vehicle; the front laserradar group is also used for detecting the obstacle condition in a left front motion path and a right front motion path of the unmanned vehicle; the rear laser radar group is used for detecting the obstacle condition in the rear side of the unmanned vehicle; the vehicle-mounted monocular vision camera is used for recognizing a sign in front of the unmanned vehicle and together with the vehicle roof laser radar and the front laser radar group in match, detecting the obstacle condition; and the control system comprises an upper computer and a lower computer; and the lower computer is a dual-corecontroller formed by an FPGA and an ARM. The price is low, the cost performance is relatively high, and the practicability is strong.