The invention discloses a propionamido-methoxyphenyl benzo [d] aza-cycloheptatriene quinazoline compound as well as preparation and application. The propionamido-methoxyphenyl benzo [d] aza-cycloheptatriene quinazoline compound provided by the invention has the obvious inhibition activity on human breast cancer cell lines MCF-7, human lung cancer cell lines A-549, human promyelocytic leukemia celllines HL-60 and human cervical carcinoma cell lines Siha, and is hopeful to be applied to the preparation of medicine for preventing or treating human breast cancer, human lung cancer, human leukemiaand human cervical cancer. The invention provides a preparation method of the propionamido-methoxyphenyl benzo [d] aza-cycloheptatriene quinazoline compound. The preparation method is simple; the operation is easy; raw materials can be easily obtained; the production cost is low; the method is suitable for practical application.