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Invention Grant
CN108117551B 取代(1H-吡唑[3,4-b]吡啶)脲类化合物及其抗肿瘤用途 有权

取代(1H-吡唑[3,4-b]吡啶)脲类化合物及其抗肿瘤用途
Abstract:
本发明提供了一种取代(1H‑吡唑[3,4‑b]吡啶)脲类化合物及其抗肿瘤用途。具体地，本发明提供了式I化合物及其药学上可接受的盐，其中，各基团的定义如说明书中所述。本发明的式I化合物可以抑制与肿瘤发生、发展相关的受体酪氨酸激酶(包括c‑Kit，PDGFRα和VEGFR2)，用于肿瘤的治疗。
Abstract(English):

The invention provides substituted (1H-pyrazolo[3,4-b]pyridine)urea compounds and antineoplastic application thereof. Specifically, the invention provides the compounds as shown in a formula I which is described in the specification. Each group in the formula is as defined in the specification. The compounds as shown in the formula I can inhibit receptor tyrosine kinases (including c-Kit, PDGFRalpha and VEGFR2) related to the occurrence and development of tumors and are used for treatment of tumors.

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