The invention relates to a Mitiglinide calcium preparation, and a preparation method thereof. The preparation method comprises following steps: Mitiglinide calcium dihydrate and accessory materials are subjected to low temperature superfine grinding; and then the Mitiglinide calcium dihydrate, lactose, starch, microcrystalline cellulose, low-substituted hydroxypropylcellulose, and sodium carboxy methyl starch are mixed, and a hydroxypropyl methylcellulose aqueous solution with an amount accounts for 1% of a prescription dosage is added; an obtained mixture is prepared into appropriate wet particles; drying and size stabilization are carried out; and after size stabilization, additives sodium carboxy methyl starch and magnesium stearate are added for mixing and tabletting.