The invention relates to a low-temperature activated sintering preparation method of high-density molybdenum materials, and belongs to the technical field of powder metallurgy. The preparation methodcomprises the steps of weighing ammonium paramolybdate and nickel nitrate hexahydrate according to Mo-x%Ni (x=0.1-1, mass fraction), adding deionized water, and preparing a mixed solution as a pecursor solution; preparing precursor powder with a spray drying method; calcinating the precursor powder in a muffle furnace; reducing hydrogen through a tubular furnace in two steps; performing high-energy ball milling to the reduced powder for 5h at 350 rpm + 6 rpm according to the ball-to-powder weight ratio of 10:1 to obtain power of which the average particle size is 190 nm; and performing die pressing to the obtained powder, and sintering the powder for 60 min at the maximum temperature of 1400 DEG C - 1750 DEG C in a high-temperature tungsten-mesh hydrogen furnace. The preparation method provided by the invention has the advantages of low sintering temperature, short sintering time, high efficiency, energy saving, high density of prepared products, small and uniform grain size, and lessimpurities.