The invention discloses a high-abrasion-resistant roll for round bar rolling as well as a manufacturing and using method of the roll, and belongs to the field of metal casting. A high-abrasion-resistant and thermal-cracking-resistant high-CrMoV alloy is adopted as an outer-layer material of the roll; the roll is manufactured through certain casting, machining and thermal treatment process methods;part of a groove bottom is lubricated by adopting a graphene thin film which is naturally produced through a special method, so as to be matched with the using process of the roll; the roll can replace a conventional NiCrMo alloy (nodular cast iron) roll, and is used for the production of a large-sized round bar of which the roll pass is relatively deep and the surface quality demand is relatively high; the abrasion resistance of the roll is improved by 1 to 2 times; the roll is free from cracking, chip falling and peeling, and integrates the relatively great anti-accident capacity and the great roll shape holding capacity; the online operation time is prolonged by 1 to 2 times or above; the rolling consumption cost per ton of steel is reduced by 10% to 20%; and accordingly, the roll canbe widely applied to the rough and intermediate rolling of large-sized round bars and section steel as well as the finished product rolling, and the large-sized round bars and the section steel are relatively deep in roll pass as well as relatively high in groove bottom abrasion resistance demand and rolled material quality demand.