The invention discloses a novel tenofovir disoproxil intermediate with a structure shown as the formula (II) in the description. The invention further discloses a preparation method of the novel tenofovir disoproxil intermediate. According to the novel tenofovir disoproxil intermediate, a new preparation path is developed for tenofovir disoproxil preparation, purification of a follow-up step is not needed, tenofovir disoproxil related substances which are associated with phosphate part in pharmacopeia can be controlled effectively, yield is high, few impurities are produced, and preparation ofhigher-purity tenofovir disoproxil is facilitated.