The invention relates to a pipeline cleaning device. The pipeline cleaning device comprises a first advancing unit, a cleaning unit and a power unit, wherein the power unit is used for providing powerfor the first advancing unit and the cleaning unit. The power unit is movably connected with the first advancing unit, the first advancing unit generates relative displacement with the power unit inthe movement direction of the pipeline cleaning device so as to drive the pipeline cleaning device to move; and the cleaning unit comprises a rotatable cleaning brush. According to the pipeline cleaning device, stains attached to the inner wall of a pipeline can be directly cleaned through the cleaning brush, and dirt inside the pipeline can be cleaned through the cleaning brush, so that the damage of a cleaning agent to parts which are easy to corrode in equipment is avoided. In addition, the pipeline cleaning device can be used for cleaning pipelines with long lengths.