The invention discloses a tetraphenylethylene-substituted tetraphenyl-porphyrin derivative. The structural formula of the tetraphenyl-porphyrin derivative is shown as a formula I. The invention also discloses a preparation method of the tetraphenylethylene-substituted tetraphenyl-porphyrin derivative. The preparation method comprises the following steps: firstly, preparing 4-(1,2,2-tristyrylphenol) benzoic acid; secondly, adding the 4-(1,2,2-tristyrylphenol) benzoic acid prepared in the first step, dicyclohexylcarbodiimide and p-N-N-dimethylpyridine into a dry organic solvent for stirring andactivating, then adding 5,10,15,20-tetra(4-hydroxyphenyl) porphyrin and p-toluenesulfonic acid and carrying out esterification reaction; after the reaction is finished, carrying out aftertreatment toobtain a product 5,10,15,20-tetra4{4-[4-(1,2,2-tristyrylphenol) ethopabate] phenyl}porphyrin. The tetraphenyl-porphyrin derivative still can emit stable red fluorescence in solid and poor solvents inan aggregation state, and the solid quantum yield can reach 7.5 percent; meanwhile, good thermal stability is achieved and the decomposition temperature is up to 455 DEG C. A preparation method provided by the invention is simple and feasible, and high yield is obtained. (The formula is shown in the description).