The invention relates to a multi-sensor information fusion-based pole tower locking method and device. The multi-sensor information fusion-based pole tower locking method comprises the steps of acquiring a target pole tower mark of a pole tower to be measured, and determining a first target position of the pole tower to be measured according to the target pole tower mark and a pre-stored navigation map; calculating a relative direction between a helicopter and the pole tower to be measured according to a first real-time position, which is acquired, of the helicopter and a first target position, and determining a pitching angle of the helicopter during flying and a horizontal rolling angle of the helicopter during flying by a flight gesture detector; controlling a pod to do horizontal rotation and/or vertical rotation according to the pitching angle, the horizontal rolling angle and the relative direction until imaging content of the pole tower to be measured is contained in a thermal image captured by an all-digital dynamic infrared thermal imager so that the pole tower to be measured is locked by the pod. Through implementing the multi-sensor information fusion-based pole tower locking method disclosed by the embodiment of the invention, the pod can be automatically controlled to lock the pole tower, manual operation is not needed, the multi-sensor information fusion-based pole tower locking method is simple to operate, and the locking accuracy and efficiency of the pole tower is improved.