An embodiment of the invention provides a proximity sensor calibration method and device, a mobile terminal and a computer readable medium and belongs to the technical field of mobile communication. The method includes: when the starting of the proximity sensor is detected, acquiring the proximity value collected by the proximity sensor according to preset calibration parameters; judging whether the proximity value is larger than a preset standard value and smaller than a preset maximum threshold; if so, updating the preset calibration parameters according to the difference between the proximity value and the preset standard value. The method has the advantages that the preset calibration parameters are updated according to the difference between the proximity value and the preset standardvalue, so that the proximity value collected by the proximity sensor according to the updated preset calibration parameters is closer to the preset standard value, and the measuring accuracy rate ofthe proximity tactile sensor is increased.