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发明公开
CN108299328A 一种治疗菌血症药物利奈唑胺及其晶型Ⅵ的制备方法 无效 - 撤回

  • 专利标题： 一种治疗菌血症药物利奈唑胺及其晶型Ⅵ的制备方法
  • 专利标题（英）： Preparation methods of medicine linezolid for treating bacteremia and crystal form VI of medicine linezolid
  • 申请号： CN201810190548.5
    申请日： 2018-03-08
  • 公开(公告)号： CN108299328A
    公开(公告)日： 2018-07-20
  • 发明人: 董丹丹
  • 申请人： 董丹丹
  • 申请人地址： 贵州省安顺市普定县城关镇红旗路晨光雅苑3#2-102
  • 专利权人： 董丹丹
  • 当前专利权人： 董丹丹
  • 当前专利权人地址： 贵州省安顺市普定县城关镇红旗路晨光雅苑3#2-102
  • 主分类号： C07D263/20
  • IPC分类号： C07D263/20
一种治疗菌血症药物利奈唑胺及其晶型Ⅵ的制备方法
摘要：
本发明公开了一种治疗菌血症药物利奈唑胺及其晶型Ⅵ的制备方法，所述治疗菌血症药物利奈唑胺晶型Ⅵ由治疗菌血症药物利奈唑胺进行制备，将治疗菌血症药物利奈唑胺置于球磨罐中，按照每100mg治疗菌血症药物利奈唑胺加入到10～20uL的四氢呋喃中，以6～12HZ的研磨频率研磨40～90min，制得治疗菌血症药物利奈唑胺晶型Ⅵ；本发明采用了原料易得、经济环保且质量上乘的制备技术，提高了反应收率，且该方法通过研磨频率与研磨时间的配合，制备得到的治疗菌血症药物利奈唑胺晶型Ⅵ光学纯度在99.5%以上，大大提高了产品的质量。
摘要（英）：

The invention discloses preparation methods of a medicine linezolid for treating bacteremia and a crystal form VI of the medicine linezolid. The crystal form VI of the medicine linezolid for treatingthe bacteremia is prepared from the medicine linezolid for treating the bacteremia. The preparation method comprises the following steps of putting the medicine linezolid for treating the bacteremia into a ball milling jar according to that every 100mg of the medicine linezolid for treating the bacteremia is added into 10mu L to 20mu L of tetrahydrofuran, and milling for 40min to 90min with the milling frequency of 6HZ to 12HZ, so as to obtain the crystal form VI of the medicine linezolid for treating the bacteremia. The preparation method adopts a preparation technique in which raw materialsare easily obtained, which is economical and environmentally friendly and the quality is further superior; the reaction yield is improved; further, the optical purity of the crystal form VI of the medicine linezolid for treating the bacteremia, which is prepared and obtained by the method, through the cooperation of the milling frequency and a milling time is 99.5 percent or above, and the qualityof a product is greatly improved.

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