The invention discloses an iterative detection method and system of wireless communication. The method comprises the following steps: performing first time demodulation on a received signal by using aQRM algorithm, descrambling and decoding the demodulated signal, and calculating a symbol mean and a sign variance according to soft bits before the hard decision of the decoder in a decoding processto serve as priori information; calculating a symbol estimated value according to the priori information, and calculating a bit soft value on the symbol estimated value by using an MMSE demodulationalgorithm, performing descrambling on the calculated data, and completing decoding; performing second time QRM soft value calculation according to the priori information and a node selection result ofthe first time demodulation, descrambling the data after the soft value calculation, and completing decoding. By adoption of the system and method, the demodulation performance is enhanced, the throughput of the user is improved, the reliability and real-time performance of the measurement signal and the control signal are improved, and the practicability is high.