The present invention provides a substituted pyrrolidine compound, a pharmaceutical composition, and applications thereof. The pyrrolidine compound is a compound represented by formula (1), or a polymorph, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, an isotope variant, a hydrate or a solvent compound thereof. The compound in the present invention can be used as a hepatitis C virus inhibitor, has better hepatitis C virus protein NS5A inhibitory activity and better pharmacokinetics/pharmacokinetics performance, and can be used in the preparation of drugs for treating hepatitis C virus infection.