The invention discloses a heavy-duty truck anti-rollover warning system based on sensing load. Suspension displacement is received by a displacement sensor; an acceleration signal is received by a transverse acceleration sensor; the two signals are processed correspondingly; the processed signals, in combination with a mechanical model calculated, are subjected to substitution to calculate valuesof left front, left rear, right front and right rear support reactions; the values are introduced into a lateral load transfer ratio LTR model to calculate real-time lateral load transfer ratio. Changes in suspension spring load pressure can be measured in real time so as to obtain the up-to-date position of a center of mass; magnitudes of support reactions at four wheels are acquired in real time; the magnitudes are introduced to the LTR model to calculate lateral load transfer ratio that has good accuracy and timeliness, and measured value and operating state delaying is relieved; dynamic load is measured by the heavy-duty truck anti-rollover warning system based on sensing load and meets the characteristics of a heavy-duty truck, high center of mass and low stability in turning.