The invention provides a rolling manufacturing method of a high-performance asymmetric three-stage differential-thickness plate. The rolling manufacturing method of the high-performance asymmetric three-stage differential-thickness plate comprises the steps that one surface of each of two aluminum alloy plate strips with completely the same size is coated with grease, and then the two aluminum alloy plate strips are stacked with the surfaces, coated with the grease, attached to each other; spot welding is conducted on the edges of the two stacked aluminum alloy plate strips, so that an aluminum alloy composite plate strip is obtained; three-stage variable-thickness rolling is conducted on the welded aluminum alloy composite plate strip, so that a continuous aluminum alloy gradient strip, namely a differential-thickness plate strip, is produced; welding spots on the edge of the rolled differential-thickness plate strip are removed; the differential-thickness plate strip is cut, so thatthree-stage differential-thickness plates in different shapes are machined; and the differential-thickness plates are separated, so that the asymmetric three-stage differential-thickness plate is manufactured. By adoption of the rolling manufacturing method of the high-performance asymmetric three-stage differential-thickness plate, continuous operation for the high-performance asymmetric aluminumalloy differential-thickness plate can be achieved, the high-performance asymmetric aluminum alloy differential-thickness plate produced through the method is expected to replace steel differential-thickness plates and steel tailor-welded plates and has broad application prospects in the fields of lightweight of automobiles and the like.