The invention discloses a control method and system for a simulation experiment device, and the method comprises the steps that control software transmits a configuration file, corresponding to the simulation experiment device, to the simulation experiment device according to the self-description information of at least one simulation experiment device; the simulation experiment device carries outthe instantiation based on the configuration file; the control file controls the simulation experiment device for a simulation experiment based on a preset control mode after instantiation. Accordingto the technical scheme of the invention, the method provides an effective means for the integrated and system integrated debugging of an intelligent transformer substation, can effectively reduce the debugging workload, and provides the debugging efficiency.