The invention relates to a heavy-thickness low-temperature high-toughness A633 MOD steel plate and a production method thereof, and belongs to the technical field of steel production. The steel plateis prepared from the chemical components in percentage by weight: 0.13 to 0.15 percent of C, 1.40 to 1.55 percent of Mn, less than or equal to 0.018 percent of P, less than or equal to 0.005 percent of S, 0.028 to 0.035 percent of Nb, 0.025 to 0.040 percent of Al, 0.15 to 0.25 percent of Ni, and the balance Fe and inevitable impurities. The production method comprises a rolling process and a quenched-tempered heat treatment process; the rolling process adopts an II type controlled rolling process; and the quenched-tempered heat treatment process adopts a normalizing and tempering process. According to the heavy-thickness low-temperature high-toughness A633 MOD steel plate and the production method thereof provided by the invention, a low-Ni component design is adopted, the deformation of the steel plate is ensured to be permeated into a heart part through controlled rolling and heat treatment processes, the structure is uniform and consistent, the overall performance is uniform and stable, and the production cost is low.