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发明公开
CN108570095A 一种促血小板聚集的多肽 有权

一种促血小板聚集的多肽
摘要：
一种促血小板聚集的多肽SITE2。本发明属于医药生物技术领域，具体涉及一种具有促进血小板聚集作用的多肽。该多肽是由12个氨基酸组成的多肽SITE2，具有SEQ ID NO:1的多肽的序列，分子量为1275.37Da，序列为Ile-Lys-Ser-Asp-Leu-Val-Asn-Glu-Glu-Ala-Thr-Gly，合成多肽后，合成的底物为完整的氨基酸序列。本多肽SITE2对凝血酶诱导的血小板聚集有显著的促进作用，可用于探索其与其它血小板激活剂对血小板的作用及相关功能的影响，还可以用于监测现有的抗血小板治疗，并可应用于制备促进血小板聚集、止血及治疗心血管疾病药物等。
摘要（英）：

A polypeptide SITE2 to promote platelet aggregation is provided. The invention belongs to the technical field of medical biology and particularly relates to a polypeptide to promote platelet aggregation. The polypeptide is polypeptide SITE2 composed of 12 amino acids, having a polypeptide sequence in SEQ ID NO: 1, and molecular weight of 1275.37 Da, wherein the sequence is Ile Lys Ser Asp Leu ValAsn Glu Glu Ala Thr Gly; after the polypeptide is synthesized, synthesized substrate is a complete amino acid sequence. The polypeptide SITE2 can significantly promote platelet aggregation induced bythrombin, is applicable to the research the effect of the polypeptide and other platelet agonists upon platelets and related functions, is also applicable to the monitoring of existing anti-platelet therapies, and is applicable to the preparation of drugs to, such as, promote platelet aggregation, stop bleeding, and treat cardiovascular diseases.

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