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发明公开
CN108623490A (2Z)-4-(二甲基氨基)-2-丁烯酸盐酸盐的合成方法 无效 - 撤回

(2Z)-4-(二甲基氨基)-2-丁烯酸盐酸盐的合成方法
摘要：
本发明公开了一种(2Z)-4-(二甲基氨基)-2-丁烯酸盐酸盐的合成方法，包括以下步骤：在惰性气体氛围下，将[双(2,2,2-三氟乙氧基)氧膦基]乙酸甲酯溶解于有机溶剂中，加入锂试剂，加入碱的溶液，控制温度为0℃至30℃，再加入2-(二甲基氨基)乙醛亚硫酸盐，搅拌反应，反应完成后通过酸化、萃取和柱纯化得到(2Z)-4-(二甲基氨基)-2-丁烯酸盐酸盐。本发明的方法操作简便，收率高，可实现工业化生产。
摘要（英）：

The invention discloses a synthetic method for (2Z)-4-(dimethylamino)but-2-enoic acid hydrochloride. The synthetic method comprises the following steps: under an inert gas atmosphere, dissolving [bi(2,2,2-trifluoroethoxy)-phosphinyl]methyl acetate in organic solvent, adding lithium reagent, adding alkali solution, controlling the temperature to 0-30 DEG C, adding 2-(dimethylamino)acetaldehyde sulfite, and carrying out stirring reaction, carrying out acidification, extraction and column purification after reaction to obtain the (2Z)-4-(dimethylamino)but-2-enoic acid hydrochloride. The syntheticmethod has the advantages of convenience in operation and high yield, and industrial production can be realized.

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