The embodiment of the invention provides a method and device used for analyzing boiler four-tube leakage and a machine readable storage medium and belongs to the technical field of a power plant. Themethod comprises the steps of collecting pre-determined sample data, used for analyzing four-tube leakage, of at least one factor in the first preset time segment and immediate data of each factor inthe second preset time segment; calculating the arithmetic mean value of the sample data of each factor to serve as ordinary value of the factor; calculating the arithmetic mean value of the immediatedata of each factor to serve as the current value of the factor; calculating the deviation percentage of the current value, relative to the corresponding ordinary value, of each factor; and on the basis of the deviation percentage of each factor, carrying out early warning analysis. Through the technical scheme, effective early warning analysis can be carried out on four-tube leakage automatically, workloads of an operator are reduced, and effective early warning of the four-tube leakage is achieved.