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发明公开
CN108689828A 一种2-苯基环丙烷-1-羧酸合成方法 无效 - 驳回

一种2-苯基环丙烷-1-羧酸合成方法
摘要：
本发明提供一种2‑苯基环丙烷‑1‑羧酸合成方法，具体涉及化合物制备技术领域，包括如下步骤：S1、将磷酰基乙酸三乙酯和催化剂在醚类惰性溶剂中溶解，在一定反应温度下滴加氧化苯乙烯，并在该温度下反应一定时间，得到中间产物2‑苯基环丙烷甲酸乙酯；S2、将所述S1步骤的反应液浓缩去除有机溶剂，加入碱液水解，再用酸液进行酸化，过滤，烘干得到最终产物2‑苯基环丙烷‑1‑羧酸。本发明具有制备方法简单，提高收率的优点。
摘要（英）：

The invention provides a synthesis method of 2-phenylcyclopropane-1-carboxylic acid and particularly relates to the technical field of compound preparation. The synthesis method includes steps of: (S1) dissolving triethyl phosphonoacetate and a catalyst in an ether inert solvent, dropwise adding phenylethylene oxide at certain reaction temperature, performing a reaction for certain time at the temperature to obtain an intermediate product, ethyl 2-phenylcyclopropaneformate; (S2) concentrating the reaction liquid in the (S1) to remove organic solvent, adding an alkaline solution for hydrolysis,acidifying the reaction liquid with acid solution, and filtering and drying the product to obtain the final product, 2-phenylcyclopropane-1-carboxylic acid. The synthesis method has simple steps andis improved in yield.

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