The invention discloses a main station and substation integrated modeling system and method based on a wide area service bus, and the method comprises the steps: building the wide area service bus which is suitable for a power real-time monitoring environment between a scheduling main station and a transformer substation (substation); respectively deploying a corresponding integrated collaborativeservice at an intelligent grid scheduling control system and a transformer substation monitoring system, thereby achieving an integrated model management function, and achieving the wide area interaction of the main station and substation integrated application services. The scheduling main station and transformer substation systems at all levels can be connected longitudinally, and three safetypartitions of the transformer substation can be connected laterally, thereby achieving the longitudinal and lateral flexible call of services and information interconnection and intercommunication, and providing a support for the applications of various types of integrated collaborative services. The system and method lay a model foundation for the collaboration of the main station and substationintegrated application, and supports a mode that the scheduling main station carries out the panoramic observation of the transformer substation.