The invention provides a comprehensive treatment method of copper-containing sludge and a circuit board. The comprehensive treatment method comprises the following steps that the copper-containing sludge and waste activated carbon are mixed and granulated to obtain copper-containing sludge particles; and side-blowing smelting is carried out on the copper-containing sludge particles and the circuitboard. The waste activated carbon is used as a reducing agent and partial combustion agent, and is mixed and granulated with the copper-containing sludge and then is subjected to side-blowing smelting with the circuit board, and waste mineral oil is used as the supplementary fuel, so that the energy consumption cost of side-blowing smelting is further reduced; and in addition, organic matters arecombusted to generate heat in the side-blowing smelting process of the circuit board, and the organic matters can be used as fuel for side-blowing smelting, so that the separation of copper metal andother impurities in the copper-containing sludge and the circuit board is completed, the heat energy of the organic matters in the circuit board is fully utilized, and the energy consumption cost ofside blowing smelting is further reduced.