The invention discloses a door-opening collision avoidance system and method suitable for an automatic driving vehicle. The system consists of a CAN bus module, a human and vehicle identification module, an information preprocessing module, a door-opening collision avoidance control ECU, a vehicle door lock driving module and a vehicle door lock execution module. The human and vehicle identification module obtains a coordinate of an individual relative to a camera from the camera. The information preprocessing module obtains a distance and a coordinate of the individual relative to a laser range finder from the laser range finder, obtains a coordinate and a speed value and direction of the individual relative to a radar sensor from the radar sensor, and integrates the coordinates, distance, speed value and direction into a coordinate, a distance and a speed value and direction of the individual relative to the vehicle. The door-opening collision avoidance control ECU calculates time needed by the individual to reach the position of the vehicle according to the speed and distance from the vehicle of the individual, compares the time with corresponding preset and generates a vehicledoor unlocking instruction. The system is simple and low in installation difficulty. The door-opening collision avoidance function of the automatic driving vehicle can be realized with extra hardware.