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发明授权
CN108721616B 一种禽巴氏杆菌荚膜多糖-蛋白结合疫苗及其制备方法 有权 转让

一种禽巴氏杆菌荚膜多糖-蛋白结合疫苗及其制备方法
摘要：
本发明属于生物技术领域，具体涉及一种禽巴氏杆菌荚膜多糖‑蛋白结合疫苗及其制备方法。本发明提供的禽巴氏杆菌荚膜多糖‑蛋白结合疫苗，由禽巴氏杆菌荚膜多糖与白喉类毒素载体蛋白通过纳米微球连接而成，采用多杀性巴氏杆菌荚膜多糖与载体蛋白白喉类毒素结合，增强了疫苗免疫效力，并对同源菌株和异源菌株的感染起到了交叉保护的作用。本发明提供的禽巴氏杆菌荚膜多糖‑蛋白结合疫苗的制备方法，操作简单，节约成本，具有良好的应用前景。
摘要（英）：

Belonging to the technical field of biology, the invention in particular relates to a pastevula mulfocida capsular polysaccharide-protein conjugate vaccine and a preparation method thereof. The pastevula mulfocida capsular polysaccharide-protein conjugate vaccine provided by the invention is formed by connection of pastevula mulfocida capsular polysaccharide and diphtheria toxoid carrier protein through nano-microspheres. The combination of pastevula mulfocida capsular polysaccharide with the carrier protein diphtheria toxoid enhances the immune efficacy of the vaccine, and also reaches a cross protection effect on the infection of homologous strains and heterologous strains. The preparation method of the pastevula mulfocida capsular polysaccharide-protein conjugate vaccine provided by theinvention has the characteristics of simple operation and cost saving, and has good application prospect.

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