The invention discloses a coordinate system fusion and rotating shaft calibration method for multiple laser profile sensors. The method, by means of a plurality of area array cameras, fuses the measurement coordinates of multiple line laser profile sensors calibrates a rotating shaft in a line laser profile sensor measurement coordinate system, and is used for the fast and high-precision rotation3D measurement of large revolution parts. The multi-camera-assisted coordinate system fusion and rotating shaft calibration method for multiple laser profile sensors does not depend on the installation precision of a mechanical structure, greatly reduces an equipment installation requirement and improves measurement accuracy. Further, the coordinate system fusion and rotating shaft calibration effectively uses the measurement speed and accuracy of the line laser profile sensor which has measurement speed multiple times higher than that of a conventional area array camera and line laser model,thereby contributing to the online measurement of large revolution parts.