The present invention discloses a novel transformer substation active noise reduction device based on theory of employing nose to treat noise. A sound pressure collection device employs a high-precision sound pressure sensor to collect noise signals (main transformer noise) of the transformer and outputs the noise signals to a DSP main control system module, the DSP main control system module outputs the control signals to an anti-noise output module, the anti-noise output module receives the control signals and then output anti-noise sound waves (having the same frequency as the main transformer, an amplitude opposite to that of the main transformer and a phase opposite to that of the main transformer) at an infrasound field, the anti-noise sound waves and the main transformed are overlapped in the space field to reduce the amplitude, perform noise reduction, reduce the noise and the power consumption and reduce the noise reduction cost.