The invention discloses an FD-TPSR network system and a relay node partial interference cancellation method and a destination node receiving signal detection method thereof. The FD-TPSR network systemcomprises a half-duplex source node, a first full-duplex relay node, a second full-duplex relay node and a half-duplex destination node; the source node is in wireless connection with the first full-duplex relay node and the second full-duplex relay node respectively; the first full-duplex relay node and the second full-duplex relay node are in wireless connection, and the first full-duplex relaynode and the second full-duplex relay node are in wireless connection with the destination node respectively; the source node is provided with a channel coding module and a binary phase shift keyingmodulation module; the relay nodes are both provided with a full-duplex communication module, an amplification and forwarding module, a channel state information acquisition module, a network synchronization module and an orthogonal transmission module; and the destination node is provided with a channel state information acquisition module, a matching filter module and a parallel interference cancellation module. The scheme has the beneficial effect that: by establishing a novel FD-TPRS network system, the advantages of simplified design, low computational complexity, low hardware cost, simple structure and short processing delay can be achieved.