The invention provides an array substrate, a display panel, a driving method of the display panel and a display device. The array substrate comprises a plurality of pixel units arranged in an array, and each pixel unit comprises at least four sub-pixel units which display different colors. For each row of pixel units, the polarities of the sub-pixel units displaying the same color in every two adjacent pixel units are different. The polarities of the sub-pixel units for displaying the same color in every two adjacent pixel units in each row of pixel units of the array substrate are different,so that the color error problem is avoided when the array substrate is operated, the display effect is greatly improved, and the user experience is enhanced.