The invention relates to the technical field of fasteners, in particular to a quick-release nut. The nut is matched with a screw. The quick-release nut comprises a first ferrule, at least one threadedblock and a second ferrule which are sequentially arranged from bottom to top; the upper end surface of the first ferrule is provided with slide grooves, and the slide grooves are in slide fit with limiting slide blocks arranged on the outer sides of the threaded blocks; the inner sides of the threaded blocks are provided with internal threads which are matched with an external thread of the screw in a screw joint mode; the limiting slide blocks are connected with a guide piece, and the guide piece is in slide fit with equal-width circular-arc grooves formed in the second ferrule; the offsetdistance exists between the circular arc center of each circular-arc groove and the center of the second ferrule, and the ends, close to the center of the second ferrule, of the circular-arc grooves serve as the tightening ends; the second ferrule rotates in the circumferential direction to drive the guide piece and the threaded blocks to do radial movement along the slide grooves; and when the guide piece is located at the tightening ends of the circular-arc grooves, the threaded blocks rotate along with circumferential rotation of the second ferrule. Through the quick-release nut, the problems that in the prior art, common nuts are inconvenient to disassemble and assemble, and quick-release nuts are complex in structure and high in manufacturing difficulty can be solved.