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发明公开
CN108853501A 磁感蛋白在改善神经退行性疾病中的应用 有权 质押

磁感蛋白在改善神经退行性疾病中的应用
摘要：
本发明涉及磁遗传学领域，尤其涉及磁感蛋白在改善神经退行性疾病中的应用。本发明通过实验证明，将磁感应蛋白导入PD细胞结果表明，在磁场作用下，PD细胞存活率得到提高，PD细胞中α‑synuclein、GSK‑3β水平被降低。将磁感应蛋白导入AD大鼠模型，在磁场作用下，AD模型大鼠海马CA1区Bcl‑2表达升高、Bax蛋白表达降低，大鼠的学习、记忆能力得到提高。由此证明磁感应蛋白能够具有改善神经退行性疾病的作用。本发明还提供了改善神经退行性疾病的药物，该药物包括磁感应蛋白或表达磁感应蛋白的基因工程载体。
摘要（英）：

The invention relates to the field of magnetic genetics, and particularly relates to application of magnetic induction protein to improvement of neurodegenerative diseases. According to the application of magnetic induction protein to improvement of the neurodegenerative diseases disclosed by the invention, an experiment proves that the magnetic induction protein is imported into PD cells so thata result shows that a survival ratio of the PD cells is increased under the effect of a magnetic field, and alpha-synuclein and GSK-3beta levels in the PD cells are reduced; the magnetic induction protein is imported into an AD rat model; under the effect of the magnetic field, Bcl-2 expression of AD-model rat hippocampus CA1 area is increased, and Bax protein expression is reduced, and the learning and memory abilities of the rats are improved; therefore, the magnetic induction protein has the effects of improving the neurodegenerative diseases. The invention also provides the medicine for improving the neurodegenerative diseases, and the medicines comprise magnetic induction protein or gene engineering carriers for expressing the magnetic induction protein.

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