The invention provides a selective hydrogenation method for pyrolysis gasoline. A single-stage adiabatic fixed-bed reactor is adopted, and the reactor is provided with a Pd-Mo-based hydrogenation catalyst. The hydrogenation process conditions are as follows: reaction temperature 30-120 DEG C, reaction pressure 2-6 MPa, airspeed 0.5-4h-1, hydrogen-to-oil volume ratio (100-600):1. One part of the hydrogenation product is used as the inner cycle of a one-stage hydrogenation reaction, and the other part is sent to a second-stage hydrogenation reactor for hydrorefining. The catalyst having a specific crystal form prepared by using a nickel-containing alumina carrier in the invention can greatly improve the dispersion and utilization rate of active metals, and the addition of selected auxiliaryactive components which are added plays a synergistic role to improve the hydrogenation activity and stability of the catalyst.