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发明公开
CN108929268A 手性1,2-二胺化合物及其合成方法 有权

手性1,2-二胺化合物及其合成方法
摘要：
本发明公开了一种手性1,2-二胺化合物的合成方法。该方法包括下列步骤：有机溶剂中，将化合物a1与化合物b1进行如下所示的偶联反应，制得如式A所示的手性1,2-二胺化合物。本发明的手性1,2-二胺化合物，在配体的设计和有机小分子催化剂的设计上显示出独特的优势；且本发明的合成方法原料简便易得，反应条件温和、可操纵性强、便捷高效。
摘要（英）：

The invention discloses a synthetic method of a chirality 1,2-diamine compound. The method comprises the following steps: a compound a1 and a compound b1 are subjected to a coupled reaction as shown below in an organic solvent to obtain the chirality 1,2-diamine compound as shown in a formula A. The chirality 1,2-diamine compound displays unique advantages in design of ligands and in design of small organic molecule catalysts; and the synthesis method of the invention is simple and easily available in raw material, is mild in reaction condition, is strong in maneuverability, and is convenientand efficient.

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