A manufacture process of wire harness shield wire disclosed in the invention includes three conductive wire cores, the periphery of the three conductive wire cores is provided with a sheathing layer in turn, each wire core is composed of tinned copper wire core conductor, inner semiconducting layer insulating rubber layer and insulating shield layer serving as ground wire, wherein the inner semiconducting layer, insulating rubber layer and insulating shield layer serving as ground wire are arranged on the periphery of the tinned copper wire core conductor in turn; The sheath layer is arrangedin a separate chamber formed by an insulating tape and a hot-melt aluminum foil wrapping layer, wherein the hot-melt aluminum foil wrapping layer is arranged on the inner side of the insulating wrapping tape, A shield sheet is arranged on that outside of the conductive wire core, The shielding sheet is wrapped around the conductive wire core in a state parallel to the conductive wire core, the shielding sheet is in an elongated shape along the longitudinal direction of the conductive wire core, the shielding sheet is staggered braided with copper fibers and has a star spiral shape on the outerside, and the spiral groove on the inner side of the shielding sheet is filled with synthetic resin.