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发明公开
CN109020810A 一种连续合成甲基丙二酸二乙酯的方法 无效 - 撤回

一种连续合成甲基丙二酸二乙酯的方法
摘要：
本发明属于有机合成技术领域，具体涉及一种连续合成甲基丙二酸二乙酯的方法。本发明通过利用2‑氯丙酸连续氰化得到2‑氰基丙酸，反应得到的2‑氰基丙酸与乙醇在硫酸的作用下进行酯化一步直接得到甲基丙二酸二乙酯粗品，经洗涤、蒸馏得到产品。反应过程简单，反应水解、酯化收率高。
摘要（英）：

The invention belongs to the technical field of organic synthesis, and specifically relates to a continuous synthesis method of diethyl methylmalonate. 2-chloropropionic acid is continuously cyanidedto obtain 2-cyanopropionic acid; 2-cyanopropionic acid and ethanol carry out esterification reactions under the action of sulfuric acid to obtain a crude product of diethyl methylmalonate directly inone step; and the finished product is obtained after steps of washing and distillation. The reaction process is simple, and the yields of hydrolysis and esterification are high.

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