The invention relates to a quaternary compound antioxidant, and concretely relates to a quaternary compound antioxidant containing four natural anti-oxidants as active components. The quaternary compound antioxidant has the inherent advantages of safety and low toxicity by using the natural antioxidants as the active components; at the same time, the quaternary compound antioxidant can fully exertthe synergistic effect of four natural antioxidants, which can greatly extend the shelf life of a sample without addition of the antioxidant, and the effect is significantly better than the various natural antioxidant monomers as well as the commercially available ternary compound antioxidants. Therefore, the quaternary compound antioxidant of the present invention can be advantageously used in the food industry.