The invention discloses an expressway hazardous chemicals vehicle passing reservation system, which solves the problem that the running of the existing hazardous chemicals vehicles is difficult to manage on the expressway. The system mainly comprises a hazardous chemicals vehicle passing reservation platform and a hazardous chemicals vehicle release device. The hazardous chemicals vehicle passingreservation platform comprises a registration module, a check module, a user generation module, a storage module, a route planning module, an identification code generation module and a first communication module. The hazardous chemicals vehicle user registers the user information through the hazardous chemicals vehicle passing reservation platform, and fills in the qualification information and the vehicle identification information of the vehicle personnel during the registration via the registration module. Only the above-mentioned information conforms to the national regulations can the registration be successful, otherwise the registration fails. The system not only cracks down on the illegal transportation of hazardous chemicals, but also ensures that the personnel on the hazardous chemicals transport vehicles entering the expressway had the basic knowledge of hazardous chemicals safety.