The invention discloses a novel zinc oxide desulfurization technology. By using a traditional reduction furnace and a fuming furnace together, a multi-phase pneumatic desulfurization tower is built, zinc oxide generated by the fuming furnace is used as a desulfurizer, and the desulfurizer can be sent to a zinc electrowinning workshop for being used as a raw material after being subjected to filterpressing, so that important measures of improving the comprehensive utilization rate of resources, reducing energy consumption and conducting clean smelting are achieved; moreover, an advanced technology is adopted for conducting individual desulfurization on furnace interior fume, so that the novel zinc oxide desulfurization technology has the characteristics of a short technology process, low processing cost, comprehensive utilization of the resources and the like, and the novel zinc oxide desulfurization technology has good demonstration and popularization effects in the industry.