The invention provides a multi-objective optimal dispatching method of a power system based on a two-layer consistency algorithm. The process comprises the following steps: establishing a multi-objective optimal dispatching model of the power system; searching for the best condition; designing a two-level consistency algorithm to find out the optimal output of the generator and calculating the minimum value of comprehensive expectation. The invention considers the influence of the transmission loss on the system supply-demand balance and the unit output optimization, and can realize the real-time calculation of the transmission loss. The multi-objective optimization problem is transformed into a single objective optimization problem by using linear weighted sum method. The supply side cansatisfy its own interests by adjusting the weighted coefficient according to the demand of the enterprise. The optimal configuration of electric energy is realized, and the supply side is guided to make a reasonable capacity plan. On the premise of considering the transmission loss, it can meet the user's load demand and improve the economic benefit and social environmental protection benefit of the enterprise. Low dependence on communication and effective protection of enterprise and user privacy, and can achieve plug and play group and effectively respond to network topology changes.