The embodiment of the invention provides a vibration isolation supporting seat core material, a friction core vibration isolation supporting seat and a preparation method and application thereof, andrelates to the technical field of vibration isolation. The vibration isolation supporting seat core material comprises steel sand, zirconia particles and rubber particles, and is prepared by mixing particle materials with different hardness and wear resistance. According to a dry friction energy consumption mechanism, energy generated by an earthquake is converted into heat for consumption throughthe friction between the core material particles. The vibration isolation supporting seat prepared by the vibration isolation supporting seat core material has the characteristics of high damping, strong energy consumption capability and excellent vibration isolation performance; and in addition, as the stiffness is horizontal and equivalent, and the stiffness do not change much with the decreaseof temperature at low temperature, the vibration isolation effect can be better maintained, and the vibration isolation supporting seat can be better used in vibration isolation structures.