The invention provides an intelligent cloud gateway of the industrial IoT and a communication method of the gateway. The gateway comprises a data collection module, a protocol analysis and conversionmodule and a cloud transmission module; the data collection module obtains industrial data collected by network equipment in the heterogeneous network; the protocol analysis and conversion module analyzes protocols of the industrial data, converts the industrial data with the different communication protocols into OPC UA standard data, and further converts the obtained OPC UA standard data into MQTT protocol data; and the cloud transmission module transmits the MQTT protocol data to a cloud platform. Thus, the industrial data with the different protocols is sent to the cloud via the single gateway, different network device access schemes are provided, and the difficulty in transmitting the multi-protocol industrial data to the cloud in the heterogeneous network is solved; and the securityof data transmission is ensured comprehensively in the network, transmission and application layers, and a complete security guarantee system is formed.