Belonging to the field of medicine, the invention in particular relates to an amino alcohol derivative shown as formula I, a pharmaceutically acceptable salt, a solvate, a polymorph or a prodrug thereof. In addition, the invention also relates to a pharmaceutical composition containing the above substances and use of the substances in preparation of drugs for preventing and treating immune inflammation or immune activity related diseases or illnesses, like multiple sclerosis, amyotrophic lateral sclerosis, CIDP, systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, psoriasis,polymyositis, etc.