The invention discloses an anti-oxidation laser cleaning device. The anti-oxidation laser cleaning device comprises a sealing box, wherein a laser device leading-in device is arranged on the sealing box, an air suction device and an air blowing device are oppositely arranged, and the air suction device and the air blowing device are fixed at the two ends of an object supporting table; the object supporting table is used for placing a workpiece, and the laser device leading-in device is used for introducing laser beams and making the laser beams to be irradiated on the workpiece; and the air blowing device is connected with a gas tank arranged outside the sealing box through a first pipeline, the gas tank is used for storing inert gas, the air suction device is connected with a cooling boxarranged outside the sealing box through a second pipeline, and the cooling box communicates with the first pipeline through a third pipeline. According to the anti-oxidation laser cleaning device, the workpiece is subjected to laser cleaning in the sealing box, the inert gas is introduced into the sealing box during the cleaning process, so that laser cleaning is carried out under the approximateoxygen-free conditions, and the surface of the workpiece is prevented from being oxidized due to oxygen and high temperature conditions in the laser cleaning process; and laser cleaning pollutants are collected, so that the pollutants are prevented from affecting the body health of operators and polluting the environment.