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发明公开
CN109384704A 一种阿普斯特的制备方法 无效 - 驳回

一种阿普斯特的制备方法
摘要：
本发明涉及一种式I所示的阿普斯特的制备方法，所述的方法包括式II在反应溶剂中与式III化合物反应制得阿普斯特粗品，经丙酮和乙醇结晶得到阿普斯特成品。该方法获得的阿普斯特纯度大于99.3%，收率大于80%，工艺简单，成本低。
摘要（英）：

The present invention relates to a preparation method of apremilast represented by a formula I, wherein the method comprises: carrying out a reaction on a compound represented by a formula II and a compound represented by a formula III in a reaction solvent to obtain an apremilast crude product, and crystallizing with acetone and ethanol to obtain the finished apremilast. According to the presentinvention, the apremilast obtained by the method has the purity of more than 99.3% and the yield of more than 80%, the process is simple, and the cost is low. The formulas I, II and III are defined inthe specification.

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