The invention relates to fused bicyclic compounds and an application thereof in medicines, and particularly discloses novel fused bicyclic compounds used as an ASK1 activity regulator, stereoisomers,geometric isomers, tautomers, nitric oxides, hydrates, solvates, metabolites, pharmaceutical acceptable salts or predrugs of the fused bicyclic compounds as well as an application of the compounds inpreparation of medicines for treating ASK1 regulated diseases and/or illness. The invention further discloses pharmaceutical containing the compounds and a method for treating ASK1 regulated diseasesand/or illness with the compounds or the pharmaceutical composition of the compounds.