The invention discloses cold protective clothing with heating devices and a manufacturing method of the cold protective clothing, and belongs to the technical field of cold protective clothing. The cold protective clothing comprises a coat, a coat inner container, trousers and a trousers inner container. The nine heating devices are placed on the outer layer of a lining of the coat inner containerand the outer layer of a lining of the trousers inner container, located on the two sides of the center of the front chest, the two sides of the center of the abdomen, the back, left and right forearms, left and right shanks and the like respectively, and are arranged to be at four levels of heating temperatures. The two sides of the center of the abdomen are arranged to be at the first level, and the temperature ranges from 38 DEG C to 43 DEG C; the back is arranged to be at the second level, and the temperature ranges from 43 DEG C to 48 DEG C; the two sides of the center of the front chestand the left and right forearms are arranged to be at the third level, and the temperature ranges from 48 DEG C to 53 DEG C; the left and right shanks are arranged to be at the fourth level, and thetemperature is 53 DEG C or higher. According to the cold protective clothing, the thermal physiological response mechanism of the human body is used from the human body physiological perspective, andthe heating devices are reasonably and effectively applied to the clothing so that on the one hand, the heating requirement of the human body for cold protective clothing can be comprehensively and effectively met, and on the other hand, a reasonable basis and reference can be provided for application of other intelligent heating devices in clothes.