The invention discloses an auxiliary clamping device for a medical guide wire. The auxiliary clamping device comprises a clamping base and a spanner; the clamping base is in a stepped cylindrical shape formed by a clamping cylinder and a handle cylinder which are coaxial, the clamping cylinder is connected with the handle cylinder through a transitional cambered surface, the side wall of the clamping cylinder is provided with a spanner containing groove, two side walls of the spanner containing groove are provided with a second through hole and a threaded through hole respectively, the side walls of the clamping cylinder and the handle cylinder are provided with through grooves, and the peripheral surface of the handle cylinder is provided with lines; one end of the spanner is an arc curved surface, the top of the other end of the spanner is provided with a protrusion, a spanner body is provided with a first through hole, and a bolt penetrates through the second through hole, the firstthrough hole and the threaded through hole for threaded connection. The auxiliary clamping device effectively reduces the situation that a guide wire slips off due to the smooth surface of the guidewire in the guide wire rotating process, the guide wire can be removed from the clamping device at any time, and the operation time of doctors is shortened.